{"product_id":"arg-homocysteine-plus-x-previously-metabolite-formula","title":"ARG Homocysteine Plus X (Previously Metabolite Formula )","description":"\u003cp\u003eHomocysteine Plus is an updated version of the original Homocysteine Metabolite Formula, which provided the primary nutrients known to be necessary for the breakdown of homocysteine into methionine and other metabolites: vitamin B6 as pyridoxine and pyridoxal- 5’-phosphate (P5P), vitamin B12 as methylcobalamin, folate as 5-methyltetrahydrofolate (5-MTHF), trimethylglycine (TMG), and L-serine. Homocysteine Plus enhances the formula with vitamin B2 as riboflavin-5-phosphate, Setria® Glutathione, zinc, and increased amounts of activated pyridoxal-5’-phosphate.\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cbr\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003eNormal homocysteine levels have been associated with cardiovascular and cognitive health, normal metabolism, and a healthy mood. Homocysteine may affect all other methyl and sulphur group metabolism processes either directly or indirectly.\u003c\/p\u003e\n\u003cp\u003eHomocysteine is metabolised from the essential amino acid methionine. To prevent excess homocysteine accumulation, the body can degrade it through two pathways of liver detoxification, transsulphuration and remethylation. The transsulphuration pathway requires both pyridoxine and P5P as well as serine, and the remethylation pathway can involve methylcobalamin (the active form of B12), S-adenosyl-methionine (SAMe),5-methyltetrahydrofolate, zinc, and trimethylglycine.\u003c\/p\u003e\n\u003cp\u003eElevated homocysteine levels are associated with lowered levels of vitamins B6, B12, riboflavin, and folate. No correlation or only a weak correlation has been found between these individual nutrients and plasma homocysteine levels, whereas various combinations of these nutrients correlate with beneficial changes in homocysteine levels, supporting the likelihood that all these nutrients are in some way required. The combination of these nutrients works synergistically in way that any single nutrient cannot.\u003c\/p\u003e\n\u003cp\u003eTMG has been shown to be helpful when other nutrients did not improve elevated homocysteine levels. TMG can stimulate remethylation of homocysteine to dimethylglycine in some situations. Additionally, TMG’s methyl donating activity is crucial to liver function and detoxification, and TMG may protect against chemical and alcohol-related damage to the liver.\u003c\/p\u003e\n\u003cp\u003eRecently researchers noticed that homocysteine is highly responsive to riboflavin.\u003c\/p\u003e\n\u003cp\u003eFoodstuffs in North America are commonly fortified with vitamin B2 but are not in Europe, and a specific subset of European individuals with the MTHFR 677 TT genotype was found to have elevated homocysteine levels because of the lack of the riboflavin cofactor.\u003c\/p\u003e\n\u003cp\u003eIn a recent study, it was found that supplementing with zinc can reduce serum homocysteine and increase vitamin B12 and folate concentrations in individuals with certain types of blood sugar conditions.\u003c\/p\u003e\n\u003cp\u003eCysteine is a component of the tripeptide glutathione. It is the rate-limiting amino acid for glutathione production and approximately 50% of the cysteine in glutathione is derived from homocysteine in human liver cells. Antioxidant enzymes such as catalase and superoxide dismutase as well as vitamin E play key roles in enhancing the trans-sulphuration pathway that allows cysteine to build out glutathione. Homocysteine inhibits glutathione peroxidase, an enzyme that protects cells against oxidation and is necessary for normal nitric oxide production and endothelial function. Blood levels of glutathione have been shown to be negatively correlated with homocysteine levels, and supplementation with glutathione has been shown to reduce levels of homocysteine.\u003c\/p\u003e\n\u003ch3\u003e\u003cspan\u003e\u003cbr\u003e\u003c\/span\u003e\u003c\/h3\u003e\n\u003ch3\u003e\u003cspan\u003eIngredients\u003c\/span\u003e\u003c\/h3\u003e\n\u003cdiv class=\"metafield-rich_text_field\"\u003e\n\u003cp\u003e\u003cstrong\u003eServing Size:\u003c\/strong\u003e 1 capsule\u003cbr\u003e\u003cstrong\u003eServings Per Container:\u003c\/strong\u003e 90\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAmount per serving:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eRiboflavin (as Riboflavin-5-Phosphate):\u003c\/strong\u003e 10 mg\u003cbr\u003e\u003cstrong\u003eVitamin B6 (50% as Pyridoxine HCl and 50% as Pyridoxal-5-Phosphate):\u003c\/strong\u003e 30 mg\u003cbr\u003e\u003cstrong\u003eFolate (as 400 mcg of 5-Methyltetrahydrofolate [from 740 mcg [6S]-5-methyltetrahydrofolate acid, glucosamine salt]):\u003c\/strong\u003e 667 mcg DFE\u003cbr\u003e\u003cstrong\u003eVitamin B12 (as Methylcobalamin):\u003c\/strong\u003e 400 mcg\u003cbr\u003e\u003cstrong\u003eZinc (Zinc Picolinate):\u003c\/strong\u003e 5 mg\u003cbr\u003e\u003cstrong\u003eTrimethylglycine:\u003c\/strong\u003e 500 mg\u003cbr\u003e\u003cstrong\u003eL-Serine:\u003c\/strong\u003e 100 mg\u003cbr\u003e\u003cstrong\u003eL-Glutathione (reduced):\u003c\/strong\u003e 50 mg\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cp\u003e\u003cstrong\u003eOther Ingredients\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"metafield-rich_text_field\"\u003e\n\u003cp\u003eHydroxypropyl methylcellulose, magnesium stearate, microcrystalline cellulose, silicon dioxide.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"section section--tight  section-blends section-full\"\u003e\n\u003cdiv class=\"product\"\u003e\n\u003cdiv class=\"product-info__block-group accordion-group\"\u003e\n\u003cdiv class=\"product-info__block-item\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003cdiv class=\"product-info__block-item\"\u003e\n\u003cdiv class=\"metafield-rich_text_field\"\u003e\n\u003cp\u003eAs a dietary supplement, take 1 capsule daily with meals, or as directed by a healthcare practitioner.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"metafield-rich_text_field\"\u003e\n\u003cp\u003eIf you are pregnant or lactating, have any health condition or are taking any medication, consult your healthcare practitioner before use.\u003c\/p\u003e\n\u003cp\u003eStore in a cool, dry place, tightly capped, away from light. Keep out of the reach of children. Use only if safety seal is intact. Variations in product color may occur.\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eRecommended for individuals looking to support healthy methylation, cardiovascular function, or antioxidant balance.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e","brand":"Allergy Research","offers":[{"title":"Default Title","offer_id":49327031386328,"sku":"SKU 72580","price":26.8,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0766\/9717\/files\/HOMOCYSTEINE_60cdac29-1f16-4ace-9091-cbeb8945faf6.jpg?v=1770628396","url":"https:\/\/www.health-emporium.co.uk\/products\/arg-homocysteine-plus-x-previously-metabolite-formula","provider":"Health Emporium","version":"1.0","type":"link"}